Green synthetic natural carbon dots derived from Fuligo Plantae with inhibitory effect against alcoholic gastric ulcer

Introduction: Fuligo Plantae (FP), the ash that sticks to bottom of pots or chimneys after weeds burn, has long been used for its hemostatic effects and treatment gastrointestinal bleeding. Nevertheless, active ingredient FP still needs be further explored. Methods: The microstructure, optical chemical properties FP-CDs were characterized. An alcohol-induced gastric ulcer model was utilized evaluate whether pre-administration alleviated bleeding symptoms ameliorated mucosal barrier disruption. In addition, feces each group rats extracted 16S rDNA genome sequencing intestinal flora. Results: with a diameter ranging from 1.4–3.2 nm had abundant groups, which may beneficial exertion inherent activity. ulcer, as demonstrated by activating extrinsic coagulation pathway, alleviating inflammation, suppressing oxidative stress levels. More interestingly, can improve diversity dysbiosis flora in ulcer. Conclusion: These comes about illustrate momentous inhibitory on alcoholic rats, give modern methodology investigating effective FP, lay an experimental basis application clinical